Potassium ascorbate with ribose is a salt derived from vitamin C that is completely non-toxic and free from side effects. The compound can be extemporaneously (i.e. without preparation) obtained by dissolving ascorbic acid (150 mg), potassium bicarbonate (300 mg, of which 117 mg potassium) and ribose (3 mg) in water. It has a pH level that tends to neutralize in less than a minute. The components have to be dissolved in 20 cc water (about two fingers high) without using a metallic spoon (because of the potential risk of oxidation of the ascorbic acid).
Oxidative processes linked to the presence of free radicals are involved in the impetus and development of cancer. Free radicals (substances with a high chemical reactivity) are the main reason for the mechanism of oxidative stress. Living organisms tend to maintain a constant level of the concentration of these oxidizing agents to ensure normal biological processes.
Based on the studies of dr. Pantellini, we are convinced that oxidative stress damages cell membrane structures, in particular the sodium/potassium ATP-ase (also known as the Na/K pump). This causes (an initially mild) depolarization and an increasingly greater alteration of the active transport mechanism of these two electrolytes. that have very different but fundamental functions in the cellular organization; potassium is the main regulator of intracellular metabolic processes through reversible salification of amino groups and imino of enzymes and proteins in a slightly acid environment; the other, sodium, is the main regulator of the alkaline reserve of the organism at extracellular level, with reversible salification of carboxylic groups of enzymes and proteins in a more or less basic environment.
In this way we obtain an increasingly bigger modification of the acid-based environment and redox-reactions between cytoplasmic molecules.
We are convinced that this fact constitutes the activating mechanism (trigger) for mutation into a cancerogene cell. In fact, research relating to the sarcoma (malignant tumor) of Rous that was already published in the 30′s (Moraveck e Kishi) proved that the neoplastic cell is lacking potassium and is rich of sodium, with an increasingly greater imbalance along with the development of cell degeneration.
This seems to be the common denominator in all neoplastic diseases and is also verifiable through a careful evaluation of the 4 hematic electrolytes (sodium, calcium, potassium, magnesium).
The described mechanism turns out to be very dangerous for the cell when:
- it activates a rapid transfer of calcium from intracellular deposits (mitochondria), that could be responsible for mitogenic activation (i.e. cell duplication);
- it allows a considerable transport of glucose in the cytoplasm (together with sodium, SGLUT symport), with a speed that increases along with the increasingly greater alteration of the sodium/potassium pump (which is the only active control element on the two electrolytes).
These processes lead to a modification in cell respiration, with a decrease of oxiditative phosphorylation and a substantial increase of glycolysis. The production of lactic acids, formed by pyruvate reduction, is also increased. Furthermore this pyruvate reduction prevents the start of the S-phase of the mitosis and its steady decrease in the cytoplasm (for the conversion into lactic acid) takes this block on mitosis away, pushing the cell towards uncontrolled proliferation.
So we have a modification of the intracellular pH that tends to become lightly alkaline, and a modification of the cellular respiration with a significant alteration of the Krebs cycle.
These facts together tend to result in an alteration in form and action of proteins and cytoplasmic enzymes, leading to a polymerization of RNA and a transfer of incorrect information between the ‘periphery’ and the ‘operative center’ (DNA). This leads to the mutation of the nuclear DNA and carcinogenesis.
In conclusion, the following hypothesis on which we are working now is that degeneration does not arise from a direct damage in the nuclear DNA, but from a problem in the cytoplasm, which means the damage would occur at the peripherical level (cell membrane). This would actually mean that operation of DNA can be strongly influenced by various components of the same cellular environment as well as by cell-to-cell signals.
From experience and data of Dr. Pantellini first and those of the Foundation now it seems that potassium ascorbate with ribose interferes with this process in a major way; it protects the cell against oxidative stress and inhibits the uncontrolled proliferation mechanism.
The compound’s action is connected to the characteristics of potassium as ‘guiding’ cation and metabolic regulator at intracellular level and to the transporting (‘carrier’) action of vitamin C, which in this specific case performs a similar function to that of the sodium/potassium pump as a consequence of its heterocyclic structure.
The release of potassium inside a cancerous cell can provoke a corresponding runoff of sodium (hence glucose) in the intracellular environment. In this way we can obtain:
- a new modification of the local, intracellular pH
- a rapid decrease of nutritional reserves, reducing glycolysis and re-establishing the potential block on mitosis. Thus, it seems possible to inhibit the uncontrolled proliferation process.
Ribose plays a very important role in cell metabolism. It is a sugar that is directly involved in the synthesis of nucleotides. It is a fundamental forerunner in the biosynthesis of RNA and adenosine, which is an essential component in the ATP and ATP-ase sodium-potassium production (the so-called Na/K pump) and in its deoxyribose form in the synthesis of DNA.
Our body is able to produce ribose. In certain conditions, however, this process of synthesis can be limited, or worse, damaged. This fact has already been pointed out in scientific research published in the United States in the ’50s.
When taken orally, ribose is metabolized and does not interfere (at least when taking the by the Pantellini Foundation recommended doses) with glycolysis.
Using a low concentration of ribose in respect to the quantity of ascorbid acid results in its potential catalytic activity; it accelerates the process of potassium absorption in the cytoplasmic cell, also because it does not follow the vitamin C process, which is transformed into oxalic acid and will leave the body via the kidneys just a few hours after intake, and it is ‘consumed’ in a different way.
Furthermore, potassium ascorbate can effectively serve at the level of prevention, maintaining constant intracellular potassium levels.
Preventive intake of potassium ascorbate therefore has the objective to ‘protect’ the cell from the risk of degeneration.
Preventive ingestion of the compound by adults generally consists of taking one dose per day, preferably in the morning on empty stomach 15 minutes before breakfast (unless otherwise indicated based on the evaluation of blood test/parameters).
In the presence of an oncologic disease it is generally recommended to take 3 daily doses (the morning on empty stomach, 15 minutes before breakfast; and 45 minutes before lunch and dinner).
It is always advisable to have an assessment made by a competent person in order to be able to suggest the most appropriate dose for each situation.
Dr. Guido Paoli
(responsible for scientific research at the Pantellini Foundation)